Covid-19 vaccination – how bleeding, clotting events follow post the jab? This is what this report suggests
Bleeding and clotting cases following COVID vaccination in India are minuscule and in line with the expected number of diagnoses of these conditions in the country, a report submitted by the National AEFI (Adverse Event Following Immunization) Committee to the Ministry of Health and Family Welfare said
Bleeding and clotting cases following COVID vaccination in India are minuscule and in line with the expected number of diagnoses of these conditions in the country, a report submitted by the National AEFI (Adverse Event Following Immunization) Committee to the Ministry of Health and Family Welfare said.
AEFI data in India showed that there is a very miniscule but definitive risk of thromboembolic events, a government release said. The reporting rate of these events in India is around 0.61/million doses, which is much lower than the 4 cases/million reported by UK’s regulator Medical and Health Regulatory Authority (MHRA). Germany has reported 10 events per million doses, it further said.
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As of 3 April 2021, 75,435,381 vaccine doses had been administered (Covishield – 68,650,819; Covaxin – 6,784,562) and of these 65,944,106 were first doses and 9,491,275 second dose, the National AEFI committee noted.
Since the COVID-19 vaccination drive was initiated – more than 23,000 adverse events were reported through the CO-WIN platform reported from 684 of the 753 districts of the country. Of these, only 700 cases at 9.3 cases /million doses administered were reported to be serious and severe nature, a government release said quoting the report.
The study was undertaken after alerts were raised in some countries on post-vaccination “embolic and thrombotic events” on 11 March 2021 particularly with AstraZeneca-Oxford vaccine which manufactures Covishield in India.
“A decision was taken to conduct an urgent in-depth analysis of the adverse events (AE) in India in the light of the global concerns,” the government release said.
The AEFI Committee has completed an in-depth case review of 498 serious and severe events, of which 26 cases have been reported to be potential thromboembolic (formation of a clot in a blood vessel that might also break loose and carried by the blood stream to plug another vessel) events – following the administration of Covishield vaccine – with a reporting rate of 0.61 cases/ million doses.
There were no potential thromboembolic events reported following administration of Covaxin vaccine the release said quoting the study.
It is important to know that thromboembolic events keep occurring in general population as background and scientific literature suggests that this risk is almost 70 per cent less in persons of South and South East Asian descent in comparison to those from European descent, the release said.
MOHFW is separately issuing advisories to healthcare workers and vaccine beneficiaries to encourage people to be aware of suspected thromboembolic symptoms occurring within 20 days after receiving any COVID-19 vaccine.
It has advised to report the following to the health facility where vaccine was administered:
- breathlessness
- pain in chest
- pain in limbs/pain on pressing limbs or swelling in limbs (arm or calf)
- multiple, pinhead size red spots or bruising of skin in an area beyond the injection site
- persistent abdominal pain with or without vomiting
- seizures in the absence of previous history of seizures with or without vomiting
- severe and persistent headache with or without vomiting (in the absence of previous history of migraine or chronic headache)
- weakness/paralysis of limbs or any particular side or part of the body (including face)
- persistent vomiting without any obvious reason
- blurred vision or pain in eyes or having double vision
- change in mental status or having confusion or depressed level of consciousness
Any other symptom or health condition which is of concern to the recipient or the family.
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