A powerful 7.8 magnitude earthquake rocked southeastern Turkey and northern Syria early Monday, toppling hundreds of buildings and killing more than 1,300 people. Hundreds were still believed to be trapped under rubble, and the toll was expected to rise as rescue workers searched mounds of wreckage in cities and towns across the area.

Turkish city of Adana, one resident said three buildings near his home collapsed.

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"I don't have the strength anymore," one survivor could be heard calling out from beneath the rubble as rescue workers tried to reach him," said the resident, journalism student Muhammet Fatih Yavus.

Farther east in Diyarbakir, cranes, and rescue teams rushed people on stretchers out of a mountain of pancaked concrete floors that was once an apartment building.

The quake felt as far away as Cairo, was centered north of Gaziantep, a Turkish provincial capital.

It struck a region that has been shaped on both sides of the border by more than a decade of civil war in Syria. On the Syrian side, the swath affected is divided between government-held territory and the country's last opposition-held enclave, which is surrounded by Russian-backed government forces.

Turkey, meanwhile, is home to millions of refugees from that conflict. The opposition-held regions in Syria are packed with some 4 million people displaced from other parts of the country by the fighting. Many of them live in buildings that are already wrecked from past bombardments.

Hundreds of families remained trapped in the rubble, the opposition emergency organisation, called the White Helmets, said in a statement. Strained health facilities and hospitals were quickly filled with wounded, rescue workers said. Others had to be emptied, including a maternity hospital, according to the SAMS medical organisation.

"We fear that the deaths are in the hundreds," Muheeb Qaddour, a doctor, said by phone from the town of Atmeh. Turkey sits on top of major fault lines and is frequently shaken by earthquakes. Some 18,000 were killed in powerful earthquakes that hit northwest Turkey in 1999. The U.S. Geological Survey measured Monday's quake at 7.8. At least 20 aftershocks followed, some hours later during daylight, the strongest measuring 6.6, Turkish authorities said.

Buildings were reported collapsed in a wide area extending from Syria's cities of Aleppo and Hama to Turkey's Diyarbakir, more than 330 kilometers (200 miles) to the northeast.

Nearly 900 buildings were destroyed in Turkey's Gaziantep and Kahramanmaras provinces, said Vice President Fuat Oktay. A hospital collapsed in the Mediterranean coastal city of Iskanderoun, but casualties were not immediately known, he said.

"Unfortunately, at the same time, we are also struggling with extremely severe weather conditions," Oktay told reporters. Nearly 2,800 search and rescue teams have been deployed in the disaster-stricken areas, he said.