Tokyo stocks opened lower on Thursday as the Dow Jones Industrial Average losing ground overnight prompted investors to secure profits after the Nikkei's gains a day earlier.

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As of 9:15 am local time (5.45 am IST), the 225-issue Nikkei Stock Average dropped 105.76 points, or 0.49 percent, from Wednesday to 21,450.75, Xinhua news agency reported.

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The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, fell 8.46 points, or 0.52 percent, at 1,611.96.

Electric appliance, chemical and machinery-linked issues comprised those that declined the most in the opening minutes after the morning bell.