Researchers identify possible drug target for prostate cancer
The researchers examined prostate cancer cell lines that model common forms of prostate cancer that are resistant to androgen deprivation therapy. They found that BRD4, but not similar family members BRD2 or BRD3, regulates the expression of key proteins that directly contribute to prostate cancer disease progression.
Researchers have long studied a family of three closely-related proteins, called BET bromodomain proteins, composed of BRD2, BRD3 and BRD4, which regulate gene expression, Photo: Reuters