Snapping its 3-day winning streak, the NSE Nifty slipped by 55 points to 10,633.30 due to heavy selling mainly in banking and pharma sectors.
Correction in global stocks amid political turmoil in Italy and Spain and sharp fall in the rupee dented investors' sentiment.
In the overseas markets, European stocks fell amid renewed fears of a Eurozone break up risk in Italy and political turmoil in Spain.
Most Asian stocks ended lower as the political crisis in Italy worsened as a fresh election appeared likely in the Eurozone's third-largest economy.
Back home, the 50-share NSE Nifty closed at 10,633.30, down 55.35 points, or 0.52 per cent. The index hit a high of 10,717.25 and a low of 10,616.10 during the day.
It saw an intra-day movement of about 101.15 points.
On the sectoral front, PSU bank fell by 2.95 per cent followed by media 1.73 per cent, bank 1.35 per cent, private bank 1.32 per cent, pharma 1.03 per cent, finance service 1.08 per cent, realty 0.98 per cent and FMCG 0.30 per cent.
On the other hand, IT rose by 0.47 per cent, auto 0.40 per cent and metal 0.06 per cent.
Major index gainers were M&M, GAIL, HCL Tech, Bharti Airtel, IOC, Hind Petro, BPCL, TCS, Infosys and HeroMotoCo.
Losers included, ICICI Bank, SBIN, Zeel, Yes Bank, UPL, Infratel, AsianPaint, IndusIndBank and Cipla.
The market breadth remained positive. A total of 832 scrips advanced, 967 declined and 70 remained unchanged.
Total securities that have hit their price band were 248.
Turnover in the cash segment rose to Rs 30,346.75 crore from Rs 30,128.42 crore as on Monday.
A total of 15,095.12 lakh shares changed hands in 1,13,26,063 trades. The market capitalisation of the listed firms on the NSE stood at Rs 1,46,68,950.12 crore.