The S&P 500 and the Dow Jones Industrial Average were pulled lower by losses in Johnson & Johnson in early afternoon trading on Monday, while the Nasdaq hit a record high ahead of Google parent Alphabet`s earnings report.
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Investors are also focusing on the earnings of tech heavyweights as a recent rally in their shares have led to concerns about stretched valuations.
However, tech continues to be the best performing S&P sector this year.
"This week is going to be critical to see the passing of the baton from the Fed being the primary driver of the market to corporate fundamentals," said Matt Miskin, senior capital markets research analyst at John Hancock Investments.
Analysts have raised their expectations for S&P 500 earnings to 8.8 percent, compared with an 8 percent rise projected at the start of the month, according to Thomson Reuters I/B/E/S.
The market will also keep an eye on political developments in Washington, with rising doubts about President Donald Trump`s ability to legislate his pro-growth policies after the failure of the healthcare bill.
"For now, better earnings is giving the market the ability to navigate some of the uncertainty that is coming out of Washington. But going into next year, the market is likely to become more concerned if policies do not finally come through," Miskin said.
At 12:41 p.m. ET (1641 GMT), the Dow Jones Industrial Average <.dji> was down 51.23 points, or 0.24 percent, at 21,528.84 and the S&P 500 <.spx> was down 2.58 points, or 0.10 percent, at 2,469.96.
The Nasdaq Composite <.ixic> was up 10.57 points, or 0.17 percent, at 6,398.33.
Also weighing on sentiment was a larger-than-expected fall in home resales volumes for June.
Nine of the 11 major S&P 500 sectors were lower, with the defensive sectors, including utilities <.splrcu>, telecommunications <.splrcl> and consumer discretionary <.splrcd>, leading the decliners.
Declining issues outnumbered advancers on the NYSE by 1,725 to 1,086. On the Nasdaq, 1,472 issues fell and 1,303 advanced.
(This article has not been edited by Zeebiz editorial team and is auto-generated from an agency feed.)